Zhiquan Zhang, Ph.D.
Research Assistant Professor of Medicine
e-mail: zzhang@notes.cc.sunysb.edu

Dr. Zhang received his Ph.D. from the Department of Biochemistry and Molecular Biology at Oklahoma State University and did postdoctoral work at the Joslin Diabetes Center and Harvard Medical School. He was the Director of Biochemistry at Argose, Inc., Waltham, MA. Prior to joining our Division, he was a Senior Research Scientist at Duke University Medical Center.

Dr. Zhang, who has expertise in single molecule reactions, is currently focusing his research interest on cancer prevention using a range of pharmacological agents. In particular, he is developing novel strategies for cancer chemoprevention based on  modulation of the NF-κB cascade.

Selected Publications

1. M. Qing, Z. Zhang, Wöltje, K. Schumacher, M. Sokalska, JF Vazquez-Jimenez   R. Minkenberg, G.B. Mackensen,  and M.C. Seghaye. Pretreatment of Dexamethasone before Cardiopulmonary Bypass Upregulates Intrahepatic Synthesis of Interleukin-10 via the Transcription Factors Sp-1, Sp-3 and CCAAT/Enhanced-binding Protein. (Submitted, 2007)
2. Y. Wang, Z. Zhang, V. Jain, J. Yi, S. Mueller, J. Sokolov, B. Rigas, K. Levon and M.H. Rafailovich. Surface molecular imprinting-A novel approach for Biosensors. (Submitted, 2007)
3. Zhang Z., Pierce ML. and Mort AJ. Changes in homogalacturonans and enzymes degrading them during cotton cotyledon expansion. Phytochemistry. 2007 Apr; 68(8):1094-103.
4. Zhang Z. and Rigas B. NF-kB, Inflammation and Pancreatic Carcinogenesis: NF-kB as a Chemoprevention Target. (Review). Int J Oncol. 29: 185-192, 2006.
5. Zhang Z., Michelle M. Spiering, Michael A. Trakselis, Fauod T. Ishmael, Mona T. Norcum, Stephen J. Benkovic, and Gordon G. Hammes.  Architecture and assembly of the Becteriophage T4 primosome. Proc Natl Acad Sci U S A. 2005 March 1: 102(9): 3254-9.
6. Xi, J.*, Zhang, Z.*, Zhuang, Z, Yang, J., Spiering, M. M., Benkovic, S. J., and Hammes, G. G. 2005. The interaction between the T4 helicase loading protein (gp59) and the DNA polymerase (gp43): unlocking of the gp59-gp43-DNA complex to initiate assembly of a fully functional replisome. Biochemistry, 44 (21), 7747-7756. * Equally contributed.
7. Jun Xi, Zhihao Zhuang, Zhiquan Zhang Tziky Selzer, Michelle M. Spring, Gordon G, Hammes, and Stephen J. Benkovic. 2005. Exploring the role of the interaction between helicase loader gp59 and polymerase gp43 in the initiation of T4 DNA replication. Biochemistry, 44 (7), 2305 –2318.
8. Melissa Horal, Zhiquan Zhang, Robert Stanton, Antti Virkamäki, and Mary R. Loeken. The hexosamine pathway contributes to oxidative stress and neural tube defects in embryos of diabetic mothers. Birth Defects Research A. 2004; 70(8): 519-527.
9. Zhiquan Zhang, P. T. Ravi Rajagopalan, Tzvia Selzer, Stephen J. Benkovic, and Gordon G. Hammes. Single-molecule and transient kinetics investigation of the interaction of dihydrofolate reductase with NADPH and dihydrofolate. Proc Natl Acad Sci U S A. 2004 March 2: 101(9): 2764-9.
10. Rajagopalan PT, Zhang Z, McCourt L, Dwyer M, Benkovic SJ, Hammes. Interaction of dihydrofolate reductase with methotrexate: ensemble and single-molecule kinetics. Proc Natl Acad Sci U S A. 2002 Oct 15; 99(21): 13481-6.
11. Gou L, Z. Zhang, K. Green, and R.C. Stanton. Suppression of IL-1b induced nitric oxide production in RINm5F cells by inhibition of glucose-6-phosphate dehydrogenase. Biochemistry. 2002 Dec 17; 41(50): 14726-33.
12. Zhang Z., K. Apse, J. Pang and R.C. Stanton. High Glucose Inhibits Glucose 6-phosphate Dehydrogenase via cAMP in Aortic Endothelial Cells.  J. Biol. Chem. 2000. 275 (51): 40042-40047.
13. Zhang Z, J. Yu, and R.C. Stanton. A method for determination of pyridine nucleotides using a single extract. Anal. Biochem. 2000.285: 163-167.