EDUCATION AND TRAINING

• B.S. Biology, Moravian College, Bethlehem Pa. 1978
• Ph.D. Temple University, Philadelphia Pa. 1984
• Postdoctoral Fellowship, National Institutes of Health, NIAID, LID, Bethesda Md. 1983-1986

APPOINTMENTS

• Research Associate,  Stanford University, Stanford Ca.  1986--1991
• Assistant Professor, Stony Brook University, Stony Brook, NY, 1991-98
• Research Scientist, Northport VA Medical Center, Northport NY, 1991-
• Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY, 1991-
• Associate Professor, Stony Brook University, Stony Brook, NY, 1998-2007
• Molecular and Cell Biology Program, Stony Brook University, Stony Brook, NY, 2001-
• Professor, Stony Brook University, Stony Brook, NY, 2007-

CURRENT LAB MEMBERS

• Peter Alff
• Irina Gavrilovskaya, M.D., Ph.D.
• Elena Gorbunova, Ph.D.
• Varya Kirillov
• Valery Matthys
• Tim Pepini
• Nandini Sen, Ph.D.
• Adrish Sen, Ph.D.

CURRENT RESEARCH INTERESTS

• Viral Pathogenesis
• Molecular Mechanisms of Rotavirus Gene Function
• Rotavirus Regulation of Cellular Signaling Pathways
• Hantavirus Regulation of Innate Cellular Responses
• Hantavirus Reverse Genetics
• Hantavirus Entry Mechanisms and Regulation of avb3 Integrin Function
• Hantavirus Directed Permeability of Endothelial Cells
• Influenza Virus Pathogenic Mechanisms

PROFESSINAL AFFILIATIONS

• American Society for Virology
• American Society for Microbiology
• American Association for the Advancement of Science
• American Society for Biochemistry and Molecular Biology
• Editor, Journal of Virology

1. Gavrilovskaya,I. N., Shepley, M., Shaw, R, Mark H. Ginsberg,  Mackow, ER  b3 Integrins Mediate the Cellular Entry of Hantaviruses that Cause Respiratory Failure.   Proceedings of the National Academy of Sciences  95, 7074-7079, 1998.
2. Gavrilovskaya, I., Ceradini, D.,  LaMonica, R.,  Springer, K., Hjelle, B., Chen, G., Schranz, J., Fay, M. Shaw, R., Mackow, E.R.  The NY-1 Hantavirus is a serotypically distinct HPS-associated hantavirus. Journal of Clinical. Microbiology  37, 122-126, 1999. 
3. Denisova, E., Dowling, W., LaMonica, R., Shaw, R., Scarlata, S., Ruggeri, F., Mackow, ER   The Rotavirus Capsid Protein VP5 Permeabilizes Membranes., J. Virology 73 p 3147-53, 1999.
   
4. Irina N. Gavrilovskaya, Eric Brown, Mark H. Ginsberg, Mackow ER  Cellular entry of hantaviruses which cause hemorrhagic fever with renal syndrome is mediated by b3 integrins. J. Virology  73 p 3951-59, 1999.
5. Dowling, W., Denisova, E., LaMonica, R., Ruggeri, F., Mackow, ER   Membrane Permeability Changes by the Rotavirus VP5 Protein are Abrogated by Mutations in An Internal Hydrophobic Domain. J. Virology  74: p 6368-76, 2000.
6. Mackow, ER., Gavrilovskaya, I. Cellular Receptors and Hantavirus Pathogenesis In Current Topics in Microbiology and Immunology: Hantaviruses, editors: C. Schmaljohn, S. Nichol. Vol. 256, p 92-115. 2001.
7. LaMonica, R., J. Nazarova, Kocer, S., Dowling, W., Geimonen, E., Shaw, R., Mackow, E.  VP4 Differentially Regulates TRAF2 Signaling, Disengaging JNK Activation while Directing NF-kB to Effect Rotavirus Specific Cellular Responses. J. Biol. Chem.  276: 19889-19896, 2001.
8. Geimonen, E., Neff, S., Raymond, T., Kocer, S., Gavrilovskaya, I., Mackow, E.R.  Pathogenic and Non-Pathogenic Hantaviruses Differentially Regulate Endothelial Cell Responses. Proceedings of the National Academy of Sciences USA 99: 13837-13842. 2002.
9. Geimonen, E., LaMonica, R., Springer, K., Farooqui, Y., Gavrilovskaya, I., Mackow, E.R.  Hantavirus Pulmonary Syndrome-Associated Hantaviruses Contain Conserved and Functional ITAM Signaling Elements.  J. Virology. 77: 1638-1643. 2003.
10. Golantsova, N, Gorbunova, E., Mackow, E.  Discrete Domains within the Rotavirus VP5* Direct Peripheral Membrane Association and Membrane Permeability J. Virology  78, 2037-44 2004
    
11. Raymond, T., Gorbunova, E., Gavrilovskaya, I.N., Mackow, E.R.  Pathogenic Hantaviruses bind plexin-semaphorin-integrin domains present at the apex of inactive, bent avb3 integrin conformers. Proceedings of the National Academy of Sciences USA  102, p1163-8, 2005.
12. Sen, A, Agresti, D., Mackow, E.R. Hyperphosphorylation of the Rotavirus NSP5 protein is Independent of Serine 67, NSP2 or the Intrinsic Insolubility of NSP5 and Regulated by Cellular Phosphatases.   J. Virology 80: 1811-1816, 2006.
13. Alff, P.J., Gavrilovskaya, I.N., Gorbunova, E., Endriss, K., Chong, Y., Geimonen, E., Sen, N., Reich, N.C., Mackow, E.R. The Pathogenic NY-1 Hantavirus G1 Cytoplasmic Tail Inhibits RIG-I and TBK-1 Directed Interferon Responses. J. Virology 80, 9676-86, 2006.
14. Sen N, Sen A, Mackow ER., Degrons at the C terminus of the pathogenic but not the nonpathogenic hantavirus G1 tail direct proteasomal degradation. J Virology  2007 Apr;81(8):4323-30.
15. Sen, A., Sen N., Mackow ER, The Formation of Viroplasm-like Structures by the Rotavirus NSP5 Protein is Calcium-Regulated and Directed by a C-terminal Helical Domain. J. Virology, 2007 in press.

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