Department of Medicine
Dr. Robert D. Shaw

Robert D. Shaw, M.D., FACG
Associate Professor of Medicine
Chief, Gastroenterology at Northport DVA Medical Center

Department of Medicine (111E), DVA Medical Center, 79 Middleville Rd., Northport, NY 11768. 631-261-4400 x 2472

Dr. Shaw completed his GI fellowship at Stanford. He has numerous clinical and laboratory research interests in the area of host responses to intestinal infections, including H. pylori and viral agents of gastroenteritis. Roles of epithelial cytokines in host defense and pathogenesis are a special interest

EDUCATION AND TRAINING

  • B.A., Williams College, Williamstown, MA 1970
  • M.D. University of Vermont College of Mediicine, Burlington, VT 1978
  • Flex Internship, Bassett Hospital, Cooperstown, NY, 1978-1979
  • Resident, Internal Medicine, University of Wisconsin-Madison University Hospital, 1979-81
  • Fellow in Nutritional Sciences, University of Wisconsin-Madison Clinical Sciences Center, Madison, WI, 1981-82
  • Clinical Fellow in Gastroenterology, Stanford University School of Medicine, Stanford, CA 1982-83
  • Traineeship in Gastroenterology on USPHS NIH Training Grant AM 07056, Stanford University School of Medicine, Stanford, California 1983-84
  • Associate Investigator Award, Palo Alto V.A. Medical Center, Palo Alto, CA 1984-87

APPOINTMENTS
  • Assistant Professor of Medicine, State University of New York at Stony Brook, and Staff Physician, Gastroenterology, Northport V.A. Medical Center  1987-95
  • Associate Professor of Medicine, State University of New York at Stony Brook, and Staff Physician, Gastroenterology, Northport V.A. Medical Center  1995-2004
  • Chief of Gastroenterology, Northport V.A. Medical Center  2004-present

BOARD CERTIFICATION

  • National Board of Medical Examiners, 1977
  • American Board of Internal Medicine, 1979
  • American Board of Internal Medicine, Gastroenterology, 1989

CURRENT RESEARCH INTERESTS

  • Infectious Diseases of the GI tract
  • Colorectal Cancer screening and prevention
  • Combat stress and function GI disorders

PUBLICATIONS
  1. Shaw R.D., Li BUK, Hamilton JW, Shug AL, Olsen WA. Carnitine transport in rat small intestine. Amer. J. Physiol. 245(3):G376-G381, 1983.
  2. Shaw R.D., Stoner-Ma D, Estes MK, Greenberg HB. Specific enzyme-linked immunoassay for rotavirus serotypes 1 and 3. J. Clin. Microbiol. 22:286-291, 1985.
  3. Offit P, Shaw R.D., Greenberg H. Passive protection against rotavirus-induced gastroenteritis in newborn mice by monoclonal antibodies to surface proteins VP3 and VP7. J. Virol. 58:700-703, 1986.
  4. Shaw R.D., Coulsen B, Kaljot K, Offit P, Greenberg H. Functional epitope mapping of the surface proteins of rhesus rotavirus. Virology 155:434-451, 1986.
  5. Shaw R.D., Fong KF, Lozonsky J, Levine J, Maldonado B, Yolken R, Flores J, Kapikian AZ, Vo PT, and Greenberg HB. Epitope-specific immune response to rotavirus vaccination. Gastroenterology 93(5):941-50, 1987.
  6. Mackow EM, Shaw R.D., Matsui SM, Vo PT, Dang MN, and Greenberg HB. Characterization of the rhesus rotavirus VP3 gene: Location of amino acids involved in homologous and heterologous rotavirus neutralization and identification of a putative fusion region. Proc. Natl. Acad. Sci. USA 85:465-469, 1988.
  7. Kaljot K, Shaw R.D., Rubin DH, Greenberg HB. Infectious rotavirus enters cells by direct cell membrane penetration, not by endocytosis. J. Virol., 62:(4)1136-1144, 1988.
  8. Burns JW, Greenberg HB, Shaw R.D., and Estes MK. Functional and topographical analyses of epitopes on the hemagglutinin (VP3) of the simian rotavirus. J. Virol. 62(6):2164-2172, 1988.
  9. Mackow EM, Shaw R.D., Matsui SM, Vo PT, Benfield D, and Greenberg HB. Characterization of homotypic and heterotypic VP7 neutralization sites of rhesus rotavirus. Virol.,165:511-7, 1988.
  10. Flores J, Daoud G, Daoud N, Puig M, Martinez M, Perez-Schael I, Shaw R, Greenberg HB, Midthun K, and Kapikian AZ. Reactogenicity and antigenicity of rhesus rotavirus vaccine (MMU-18006) in newborn infants in Venezuela. Ped. Infect. Dis. J., 7:776-80, 1988.
  11. Shaw R.D., Mackow EM, Dyall-Smith ML, Lazdins I, Holmes IH, and Greenberg HB: Serotypic analysis of VP3 and VP7 neutralization escape mutants of rhesus rotavirus. J. Virol. 62(9):3509-12, 1988.
  12. Matsui SM, Offit PA, Mackow ER, Benfield DA, Shaw R.D., Greenberg HB. Passive protection against rotavirus-induced diarrhea by monoclonal antibodies to the heterotypic neutralization domain of VP7 and the VP8 fragment of VP4. J. Clin. Microbiol., 1989.
  13. Shaw R.D. Viral infections of the gastrointestinal tract. Current Opinion in Gastroenterology, 6:105-111, 1990.
  14. Merchant A, Groene WS, Cheng EH, and Shaw, R.D.. Murine intestinal antibody response to heterologous rotavirus infection. Journal of Clinical Microbiology 29(8):1693-1701,1991.
  15. Shaw, R.D., Groene, WS, Mackow, EM, Merchant, A, Cheng, EH. VP4-specific intestinal antibody response to rotavirus in a murine model of heterotypic infection. Journal of Virology 65(6):3052-3059, 1991.
  16. Shaw R.D. Viral infections of the gastrointestinal tract. Current Opinion in Gastroenterology 7(1):86-96, 1991.
  17. Shaw R.D. Viral infections of the gastrointestinal tract. Current Opinion in Gastroenterology 8(1):91-100, 1992.
  18. Groene, WS and Shaw, R.D.. Psoralen preparation of antigenically intact noninfectious rotavirus particles. Journal of Virological Methods 38:93-102, 1992.
  19. Shaw R.D., Groene WS, Mackow ER, Merchant AA, Cheng EH. Recombinant baculovirus-expressed rotavirus protein (VP4) in an ELISPOT assay of antibody secretion. Viral Immunology 5(1):51-59, 1992.
  20. Shaw R.D., Merchant AA, Groene WS, and Cheng EH. Persistence of Intestinal Antibody Response to Heterologous Rotavirus Infection in a Murine Model beyond 1 Year. J Virol, 31(2): 188-191, 1993.
  21. Shaw R.D. Viral infections of the gastrointestinal tract. Current Opinion in Gastroenterology 9(1):88-95, 1993.
  22. Shaw R.D. Viral infections of the gastrointestinal tract. Current Opinion in Gastroenterology 10(1)74-79, 1994.
  23. Mackow E, Fay ME, Shaw R.D., Hung T, Chen GM.  Cloning Sequencing and expression of the gene encoding the vp2 protein of the human group B rotavirus ADRV Virology 201:162-168 1994.
  24. Leichus RS, Goldhill GM, Long JD, Percy WH, Shaw R.D., Donovan V, and Burakoff R. Effects of rotavirus on epithelial transport in rabbit small intestine. Digestive Diseases and Sciences 39(10): 2202-2208, 1994.
  25. Shaw R.D., Hempson S, and Mackow ER. Rotavirus diarrhea is caused by non-replicating viral particles. J. Virol., 60(10):5946-5950, 1995.
  26. Sheth R, Anderson J, Sato T, Oh B, Hempson SJ, Rollo E, Mackow ER, and Shaw R.D. Rotavirus Stimulates IL-8 Secretion from Cultured Epithelial Cells. Virology, 221:251-259, 1996.
  27. Shaw R.D. and Hempson SH. Replication as a Determinant of the Intestinal Response to Rotavirus. J. Infect. Dis., 174(6):1328-1331, 1996.
  28. Anderson JC, Cheng E, Roeske M, Marchildon P, Peacock J, Shaw R.D. Detection of serum antibodies to Helicobacter pylori by an immunochromatographic method. Am. J. Gastroenterology, 92(7):1135-1139, 1997.
  29. Gavrilovskaya IN, Shepley M, Shaw R.D., Ginsberg MH, and Mackow EM. 3 integrins mediate the cellular entry of hantaviruses that cause respiratory failure. Proc. Natl. Acad. Sci. USA, 95:7074-7079, 1998.
  30. Gavrilovskaya IN, LaMonica R, Fay M, Hjelle B, Schmaljohn C, Shaw R, Mackow E. New York 1 and Sin Nombre viruses are serotypically distinct viruses associated with Hantavirus pulmonary syndrome. Journal of Clinical Microbiology 37(1)122-126, 1998.
  31. Noiri, E. Dickman, K. Miller, F. Romanov, G. Romanov, V. I., Shaw, R., Chambers, A. F. Rittling, S. R. Denhardt, D. T., Goligorsky, M. S. Reduced tolerance to acute renal ischemia in mice with a targeted disruption of the osteopontin gene. Acute Renal Ischemia in Mice with Targeted Disruption of Osteopontin Gene: Link to Nitric Oxide-Induced Injury. Kidney International 56(1)74-82, 1999.
  32. Shaw R.D. Viral infections of the gastrointestinal tract. Current Opinion in Gastroenterology  15(1)53-58, 1999.
  33. Denisova E, Dowling W, LaMonica R, Shaw R, Scarlata R, Ruggeri F, Mackow ER. The Rotavirus Capsid Protein VP5 Permeabilizes Membranes. Journal of Virology, 73(4)3147-53, 1999.
  34. Rollo E, Hempson S, Kumar P, Reich N, Sheth RRV, Anderson J, Oh B, Angel J, Greenberg HB, Cohen J, and Shaw RD. Intestinal chemokine response to rotavirus infection. Journal of Immunology 163(8):4442-52, 1999.
  35. Shaw RD. Viral infections of the gastrointestinal tract. Current Opinion in Gastroenterology, 16(1)12-17, 2000.
  36. Dickman KG, Hempson S, Anderson J, Lippe S, Zhao L, Burakoff R, and Shaw RD. Rotavirus Alters Paracellular Permeability and Energy Metabolism in Caco-2 Cells. Am J Physiol Gastrointest Liver Physiol 279: G757-G766, 2000.
  37. Anderson, J.C., B.J. Pollack, and R. D. Shaw, Virtual colonoscopy [letter; comment]. N Engl J Med, 2000. 342(10): p. 738; discussion 738-9.
  38. Anderson, J. C., Birk, J. W., Shaw, R. D. Comparison of colonoscopy and double-contrast barium enema. N Engl J Med 343(23): 1729; discussion 1729-30, 2000.
  39. LaMonica R, Kocer SS, Nazarova J, Dowling W, Geimonen E, Shaw R. D., Mackow ER. VP4 differentially regulates TRAF2 signaling, disengaging JNK activation while directing NF-kappa B to effect rotavirus-specific cellular responses. J Biol Chem 2001; 276:19889-96.
  40. Ellen E. Rollo,  Scott J. Hempson, Ajay Bansal, Ernest Tsao, Iman Habib,  Susan R. Rittling, David T. Denhardt, Erich R. Mackow, and Robert D. Shaw. The Cytokine Osteopontin Modulates the Severity of Rotavirus Diarrhea. J. Virol., , 79(6): 3509–3516, 2005.
  41. Anderson, J.C., Alpern, Z., Sethi, G., Messina, C.R., Martin, C., Hubbard, P.M., Grimson, R., Ells, P.F., and Shaw, R.D. 2005. Prevalence and risk of colorectal neoplasia in consumers of alcohol in a screening population. Am J Gastroenterol 100:2049-2055.
  42. Anderson JC, Messina CR, Dakhllalah F, Abraham B, Alpern Z, Martin C, Hubbard PM, Grimson R, Shaw RD. Body mass index: a marker for significant colorectal neoplasia in a screening population. J Clin Gastroenterol. 2007 Mar;41(3):285-90.
  43. Scott J. Hempson, Kristina Matkowskyj, Ajay Bansal, Ernest Tsao, Iman Habib, Richard Benya, Robert D. Shaw. Rotavirus Infection of Small Intestine Causes Colonic Secretion Through Regulation of Galanin-1 Receptor. Submitted for publication 2007.

Recent Reviews

  1. Shaw R.D. Rotavirus. In Encyclopedia of Gastroenterology, L. Johnson ed. In chief. Elsevier Academic Press, San Diego. p.307, 2004.